Our pilot study to assess feasibility and safety of intraoperative 5-aminolevulinic acid mediated photodynamic (5-ALA PDT) therapy for the treatment of newly diagnosed glioblastoma (GBM) is now open and recruiting. More info here or here.
Our paper entitled "Interstitial photodynamic therapy and glioblastoma: Light fractionation in a preclinical model" is the editor's choice of the latest issue of Laser in Surgery and Medicine.
The clinical Trial INDYGO presented during the latest International Photodynamic Association Congress (IPA - 2017) held in Coimbra, Portugal
Monday, June 11, 2017, our latest developments on Intraoperative Photodynamic Therapy for the treatment of Glioblastoma (INDYGO) has been presented at the PDT in Neurology-Brain Session during the lastest IPA congress.
Set-up of the clinical trial and first experiments on intraoperative 5-ALA PDT on newly diagnosed glioblastoma were introduced by M. Vermandel (ONCO-THAI U1189 - Inserm - Université de Lille - CHRU de Lille).
Three talks were given by members of the team to introduced the INDYGO clinical trial during the latest ALSMS conference held in San Diego. Clément Dupont presented the illumination device designed by our lab and Maximilien Vermandel presented the set-up of the clinical trial and MRI monitoring of the PDT effects.
Next april, members of the team ONCO-THAI will attend the ASLMS annual conference in San Diego (CA). This event is organized by the American Society for Laser Medicine and Surgery. Our latest researches will presented. Clément Dupont, PhD student in the lab under the supervision of Dr. M. Vermandel, has been granted by the ASLMS for his work on Phodynamic therapy for the treatment of glioblastoma.
Photodynamic therapies for the treatment of Glioblastoma will be presented during the SPIE BiOS conference held in San-Francisco (USA- January 28th- 2nd, 2017)
January 9th - 10th, Synaps held its latest consortium meeting in the University of Lille (France). This meeting was scheduled to update all partners about SYNAPS progress and mostly to prepare the upcoming final project proposal for the H2020 call on New therapies for rare diseases (SC1-PM-08-2017).
Our paper entitled "5-ALA Photodynamic Therapy in Neurosurgery, Towards the Design of a Treatment Planning System: A Proof of Concept" has been accepted in IRBM.
This paper describes a proof of concept of a treatment planning system designed to manage dosimetry issues before PDT delivery. This tool enables the planning of a whole treatment in surgical stereotactic conditions. Stereotactic registration and dosimetry components are detailed and evaluated.
Although this system remains to be perfected, this preliminary work aimed to demonstrate the feasibility of planning 5-ALA PDT treatments in stereotactic conditions. Future improvements will mainly focus on the optimization of the treatment delivery, automatic segmentation and GPU-accelerated Monte-Carlo management to take into account GBM tissue heterogeneity.
This paper is available on Science Direct or here.
Our paper entitled "Stacking denoising auto-encoders in a deep network to segment the brainstem on MRI in brain cancer patients: A clinical study" has been recently published in Computerized Medical Imaging and Graphics (vol. 52).
This paper introduces a deep learning approach based on stacking denoising auto-encoders in order to segment the brainstem on magnetic resonance images in brain cancer context. Additionally to classical features used in machine learning to segment brain structures, two new features are suggested. Four experts participated in this study by segmenting the brainstem on 9 patients who underwent radiosurgery. Analysis of variance on shape and volume similarity metrics indicated that there were signiﬁcant differences (p < 0.05) between the groups of manual annotations and automatic segmentations. Experimental evaluation also showed an overlapping higher than 90% with respect to the ground truth. These results are comparable, and often higher, to those of the state of the art segmentation methods but with a considerably reduction of the segmentation time.
This paper is available on Science Direct or here.
Pr. Reyns presenting the concept of Photodynamic Therapy for the treatment of Glioblastoma during the latest NENO meeting in Lille (France)
The NENO meeting was held in Lille November, 4th 2016 and gathered experts in Neuro-Oncology from East and North of France. This successful meeting was chaired by Dr. Emilie Lerhun and communications on hot topics from the different Neuro-Oncology domains were presented. Latest developments in Photodynamic therapies for the treatment of Glioblastoma were reported.
Pr. Mordon were invited to present Photodynamic therapies (PDT) during regional news program on France 3 (France 3 Lorraine division). This interview was achieved in the context of the "PDT update" congress held in Nancy. New technological developments in PDT were presented, and a particular attention has been paid to SYNAPS and new concepts offered by PDT to treat Glioblastoma. (Video in French)
Photodynamic therapy for the treatment of Glioblastoma presented during the PDT update held in Nancy (France - October 23rd-28th, 2016)
Clément Dupont won the 48 hours competition "Imagine Science" at the 12th Annual Pariscience Film Festival, held in Paris (October 6th-11th, 2016)
Clément Dupont, Synaps member and young researcher at the ONCO-THAI lab won the best film award of the competition. The film was produced with the filmmaker Salvo Manzone as part of the 48h Competition Imagine Science Paris during the 12th Annual Pariscience Film Festival. The film was shown during the 9th Imagine Sciences film festival held in New-York city (October 14th-21st, 2016).
French version is visible here and English version (subtitled) is visible here.
If the vegetables could helps us to understand how we can cure brain cancer? A inspiring and aesthetic film, which brings hope, showing how light can be used as a efficient treatment.