An article detailing the photodynamic therapy of glioblastomas is published in the latest issue of Nature (Nature 561, S59-S61 (2018) - doi: 10.1038 / d41586-018-06713-6) Following an interview given by M. Vermandel, C. Dupont and N. Reyns, the article presents the latest work of the OncoThAI unit, in particular the setting up of the INDYGO study . Read the article here or here.
The SATT Nord and the Rare Diseases Foundation are converging their complementary expertise to promote the emergence and maturation of research projects in the field of rare diseases in the Hauts-de-France and Champagne-Ardenne territories.
In response to the joint call for proposals launched on February 14, 2018, 10 applications were submitted by researchers and hospital physicians from the research and care centers of Lille, Amiens and Reims.
OncoThAI will attend the European Photodynamic Therapy and Photodiagnosis Update conference from September 18th to 22nd 2018 in Kochel (Germany)
From September 18th to 22nd, 2018, ONCO-THAI team members will attend the Photodynamic Therapy and Photodiagnosis Update conference in Germany.
Recently, the enrollment phase of the clinical trial INDYGO has been successfully achieved with the tenth recruitment.
As a reminder, the INDYGO study, promoted by the University Hospital of Lille and coordinated by Professor REYNS in collaboration with Professor MORDON and Dr. VERMANDEL from OncoThAI, evaluates the association of a new intraoperative laser illumination device with a photosensitizing molecule for treating newly diagnosed glioblastomas.
OncoThAI researchers presented their latest works during the ASLMS 2018 conference in Dallas
This year again, the presence of OncoThAI researchers was noticed during the 38th ASLMS Congress (American Society of Laser In Medicine and Surgery).
This edition confirmed the involvement of the OncoThAI both in terms of organization and scientific dissemination. Indeed, Prof. Serge Mordon, head of OncoThAI was co-chairman in charge of the scientific program and several papers on photodynamic therapy were presented during oral sessions.
These sessions were the occasion of scientific presentations by Dr. Maximilien Vermandel on the implementation of INDYGO clinical trial and round tables on PDT. The next edition of this conference will be held in Denver in 2019.
In the latest issue of the weekly journal Le Point Le Point (April, 5Th, 2018), an article focuses on OncoThAI's work on photodynamic therapy. This article illustrates the application of photodynamic therapy in Neurosurgery for the management of glioblastoma within the clinical trial INDYGO. Read the paper here.
Next April, ONCO-THAI team members will attend the annual ASLMS conference in Dallas, Texas.
This event is organized by the American Society for Laser Medicine and SurgeryOur work on Photodynamic Therapy will be presented in the "Clinical Applications - Multi-Specialty - Abstract Session" session (here) and the "Basic Science and Translational Research - Abstract Session" session (here). We hope to meet you there...
Recently, the clinical trial INDYGO developed by OncoThAI has been reported on the France national TV broadcast. This report describes the work carried out by researchers from the laboratory and the INDYGO clinical study conducted at the University Hospital of Lille within the Neurosurgery Dept. The report was broadcasted in the program "Le Magazine de La Santé" on France 5 on November 20, 2017. Replay is available here or here (in French)
Our newest paper on Photodynamic Therapy in a preclinical model published in Lasers in surgery and Medicine
Our paper entitled "MRI Assessment of Treatment Delivery for Interstitial Photodynamic Therapy of High-Grade Glioma in a Preclinical Model" has been published (ahead of print) in Lasers in Surgery and Medicine (LSM).
This paper introduces photodynamic therapy in a preclinical study where twenty-six “nude” rats have been grafted with human U87 cells into the right putamen before undergoing interstitial PDT treatment. It aims to evaluate MRI findings, including diffusion, and perfusion sequences, compared with immunohistological data from the same population to address the efficiency of light fractionation.
More info here.
Our latest paper introducing the medical lighting device developed for the INDYGO trial published in Future Oncology
A new device was recently released to enable optimal lighting of the surgical cavity during the neurosurgery procedure embedding Photodynamic therapy of glioblastoma. Today, this device is employed within the prospective clinical trial INDYGO.
The full description of the device including design, experimental assessment, thepreclinical study and the safety evaluation is documented in our latest paper published in Future oncology.
More info here or here.
Our paper entitled "Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models" has been published (ahead of print) in Lasers in Surgery and Medicine (LSM)
This paper introduces Photodynamic therapy (PDT) as a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues. In the present study, two analytical methods of light propagation emitted from a cylindrical fiber source were evaluated: a discrete and a continuous method.
On September 8th 2017, Pr. Bagnato gave a conference in the ONCO-THAI lab. His talk was about Photodynamic therapy and its applications. Pr. Bagnato is internationally recognized for his work in physics and photodynamic therapy and it was our great honor to welcome him in our lab for a really nice and fruitful meeting.
Maximilien Vermandel, PhD was selected by the ASLMS Research committee to receive funding for his proposal “INDYGO-Intraoperative PDT for the treatment of Glioma." His project is the first ever non-American awarded by the committee.
The website of the American Society of Laser in Surgery and Medicine reports our latest results. The complete article is available here.