Recently, a new video on photodynamic therapy to treat glioblastoma has been released on our youtube channel. This video reports application of PDT within the clinical trial INDYGO supported by OncoThAI. The video is available here.
OncoThAI researchers presented their latest works during the ASLMS 2018 conference in Dallas
This year again, the presence of OncoThAI researchers was noticed during the 38th ASLMS Congress (American Society of Laser In Medicine and Surgery).
This edition confirmed the involvement of the OncoThAI both in terms of organization and scientific dissemination. Indeed, Prof. Serge Mordon, head of OncoThAI was co-chairman in charge of the scientific program and several papers on photodynamic therapy were presented during oral sessions.
These sessions were the occasion of scientific presentations by Dr. Maximilien Vermandel on the implementation of INDYGO clinical trial and round tables on PDT. The next edition of this conference will be held in Denver in 2019.
In the latest issue of the weekly journal Le Point Le Point (April, 5Th, 2018), an article focuses on OncoThAI's work on photodynamic therapy. This article illustrates the application of photodynamic therapy in Neurosurgery for the management of glioblastoma within the clinical trial INDYGO. Read the paper here.
Next April, ONCO-THAI team members will attend the annual ASLMS conference in Dallas, Texas.
This event is organized by the American Society for Laser Medicine and SurgeryOur work on Photodynamic Therapy will be presented in the "Clinical Applications - Multi-Specialty - Abstract Session" session (here) and the "Basic Science and Translational Research - Abstract Session" session (here). We hope to meet you there...
Recently, the clinical trial INDYGO developed by OncoThAI has been reported on the France national TV broadcast. This report describes the work carried out by researchers from the laboratory and the INDYGO clinical study conducted at the University Hospital of Lille within the Neurosurgery Dept. The report was broadcasted in the program "Le Magazine de La Santé" on France 5 on November 20, 2017. Replay is available here or here (in French)
Our newest paper on Photodynamic Therapy in a preclinical model published in Lasers in surgery and Medicine
Our paper entitled "MRI Assessment of Treatment Delivery for Interstitial Photodynamic Therapy of High-Grade Glioma in a Preclinical Model" has been published (ahead of print) in Lasers in Surgery and Medicine (LSM).
This paper introduces photodynamic therapy in a preclinical study where twenty-six “nude” rats have been grafted with human U87 cells into the right putamen before undergoing interstitial PDT treatment. It aims to evaluate MRI findings, including diffusion, and perfusion sequences, compared with immunohistological data from the same population to address the efficiency of light fractionation.
More info here.
Our latest paper introducing the medical lighting device developed for the INDYGO trial published in Future Oncology
A new device was recently released to enable optimal lighting of the surgical cavity during the neurosurgery procedure embedding Photodynamic therapy of glioblastoma. Today, this device is employed within the prospective clinical trial INDYGO.
The full description of the device including design, experimental assessment, thepreclinical study and the safety evaluation is documented in our latest paper published in Future oncology.
More info here or here.
Our paper entitled "Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models" has been published (ahead of print) in Lasers in Surgery and Medicine (LSM)
This paper introduces Photodynamic therapy (PDT) as a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues. In the present study, two analytical methods of light propagation emitted from a cylindrical fiber source were evaluated: a discrete and a continuous method.
On September 8th 2017, Pr. Bagnato gave a conference in the ONCO-THAI lab. His talk was about Photodynamic therapy and its applications. Pr. Bagnato is internationally recognized for his work in physics and photodynamic therapy and it was our great honor to welcome him in our lab for a really nice and fruitful meeting.
Maximilien Vermandel, PhD was selected by the ASLMS Research committee to receive funding for his proposal “INDYGO-Intraoperative PDT for the treatment of Glioma." His project is the first ever non-American awarded by the committee.
The website of the American Society of Laser in Surgery and Medicine reports our latest results. The complete article is available here.
Our paper entitled "Interstitial photodynamic therapy and glioblastoma: Light fractionation in a preclinical model" is the editor's choice of the latest issue of Laser in Surgery and Medicine.
The clinical Trial INDYGO presented during the latest International Photodynamic Association Congress (IPA - 2017) held in Coimbra, Portugal
Monday, June 11, 2017, our latest developments on Intraoperative Photodynamic Therapy for the treatment of Glioblastoma (INDYGO) has been presented at the PDT in Neurology-Brain Session during the lastest IPA congress.
Set-up of the clinical trial and first experiments on intraoperative 5-ALA PDT on newly diagnosed glioblastoma were introduced by M. Vermandel (ONCO-THAI U1189 - Inserm - Université de Lille - CHRU de Lille).
Three talks were given by members of the team to introduced the INDYGO clinical trial during the latest ALSMS conference held in San Diego. Clément Dupont presented the illumination device designed by our lab and Maximilien Vermandel presented the set-up of the clinical trial and MRI monitoring of the PDT effects.